GMP Grade Buffers

Balanced Salt Solutions

Balancing your cell culture

Cell cultures need to be carried out under carefully regulated conditions to maintain the structural and physiological integrity of cells in vitro. Resolve’s Balanced Salt Solutions provide cells with the essential inorganic ions required for a stable pH and osmotic pressure environment. These isotonic buffer systems help keep mammalian cells and primary cells within their physiological pH range and maintain high viability during short-term incubations.

We offer ready-to-use Balanced Salt Solutions for cell culture, such as PBS and DPBS in liquid form. These balanced salt solutions are manufactured in an state-of-the-art GMP compliant and ISO 13845:2016 certified facility to ensure a consistent and premium quality solution for everyday research and are tested for physiological pH, osmolality, endotoxin, and absence of bacterial and fungal contamination. We strive to manufacture products that significantly reduce the environmental impact of the cell culture industry.

Please see below for the common formulation components found in balanced salt solutions and how they may impact your cell culture.

Selection Guides

PBS vs DPBS

Among the plethora of solutions utilized for various experimental procedures, phosphate-buffered saline (PBS) and Dulbecco’s phosphate-buffered saline (DPBS) stand out as crucial components. While both solutions share similarities, they possess distinct compositions and applications that merit exploration and understanding.

PBS and DPBS, both of which include sodium chloride and phosphate buffer, are common reagents used in biological research to maintain pH while minimizing osmotic shock in living cells; however, in contrast to PBS, DPBS also includes potassium chloride and may be formulated with or without calcium and magnesium and with or without glucose and pyruvate. Select PBS or DPBS based on your specific application.

Selection Guides

Browse balanced salt solution products

Phosphate buffered saline (PBS)

Commonly used in biological applications, PBS is a water-based salt solution with a simple formulation. It is isotonic and non-toxic for most cells. It includes sodium chloride and phosphate buffer and is formulated to prevent osmotic shock while maintaining living cells’ water balance.

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